Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

Domestication refers to artificial selection and breeding of wild species to obtain cultivated
variants that thrive in man-made niches and meet human or industrial requirements. Several …

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

Background Host-microbe associations underlie many key processes of host development,
immunity, and life history. Yet, none of the current research on the central model species …

Studies in model organisms have yielded considerable insights into the etiology of disease
and our understanding of evolutionary processes. Caenorhabditis elegans is among the …

The nematode Caenorhabditis elegans is used as a central model system across biological
disciplines. Surprisingly, almost all research with this worm is performed in the absence of its …

This Element presents a philosophical exploration of the concept of the'model organism'in
contemporary biology. Thinking about model organisms enables us to examine how living …

Five versions of the Chlamydomonas reinhardtii reference genome have been produced
over the last two decades. Here we present version 6, bringing significant advances in …

Caenorhabditis elegans has emerged as a major model in biomedical and environmental
toxicology. Numerous papers on toxicology and pharmacology in C. elegans have been …

Host genetic landscapes can shape microbiome assembly in the animal gut by contributing
to the establishment of distinct physiological environments. However, the genetic …