Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data

S Seal, D Williams, L Hosseini-Gerami… - Chemical Research …, 2024 - ACS Publications
Drug-induced liver injury (DILI) has been a significant challenge in drug discovery, often
leading to clinical trial failures and necessitating drug withdrawals. Over the last decade, the …

Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus

Z Wei, Y Fang, W Shi, Z Chu, B Zhao - International Journal of Molecular …, 2023 - mdpi.com
In order to explore the molecular regulatory mechanism of temperature acclimation under
long-term temperature stress in Acrossocheilus fasciatus, this study used high-throughput …

Effect of aflatoxin B1, benzo [a] pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells

V Tryndyak, I Kindrat, K Dreval, MI Churchwell… - Food and Chemical …, 2018 - Elsevier
The increasing number of man-made chemicals in the environment that may pose a
carcinogenic risk highlights the need for developing reliable time-and cost-effective …

Proteomic analysis of liver proteins of mice exposed to 1, 2-dichloropropane

X Zhang, K Morikawa, Y Mori, C Zong, L Zhang… - Archives of …, 2020 - Springer
Dichloropropane (1, 2-DCP) is recognized as the causative agent for cholangiocarcinoma
among offset color proof-printing workers in Japan. The aim of the present study was to …

Predicting carcinogenic mechanisms of non-genotoxic carcinogens via combined analysis of global DNA methylation and in vitro cell transformation

SH Hwang, H Yeom, BI Han, BJ Ham, YM Lee… - International journal of …, 2020 - mdpi.com
An in vitro cell transformation assay (CTA) is useful for the detection of non-genotoxic
carcinogens (NGTXCs); however, it does not provide information on their modes of action. In …

In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism

A Braeuning, A Oberemm, T Heise… - Archives of …, 2019 - Springer
The antihistaminic drug methapyrilene was withdrawn from the market in 1979 because of
hepatocarcinogenicity in rats. Since then, the drug has been used as a model hepatotoxin …

[PDF][PDF] Determination of Usnic Acid Effect on Iron Metabolism in Rat Liver

IP Kindrat - academia.edu
DETERMINATION OF USNIC ACID EFFECT ON IRON METABOLISM IN RAT LIVER Page 1
Біологічні науки 362 Український журнал медицини, біології та спорту – 2020 – Том 5, № 4 …