Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …

The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including
transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the
motor system and presents with progressive muscle weakness. Most patients survive for …

Microglia coordinate various functions in the central nervous system ranging from removing
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA‐binding …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron
degeneration, progressive motor dysfunction, paralysis, and death. Although multiple …

TDP-43 is an aggregation-prone protein which accumulates in the hallmark pathological
inclusions of amyotrophic lateral sclerosis (ALS). However, the analysis of deeply …

Fused in sarcoma (FUS) is an RNA binding protein that regulates RNA metabolism including
alternative splicing, transcription, and RNA transportation. FUS is genetically and …