Infectious diseases

H Li, N Terrando, HA Gelbard - Microglia: Physiology, Pathophysiology …, 2024 - Springer
Microglia, brain-resident innate immune cells, have been extensively studied in
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …

Orchestration of antiviral responses within the infected central nervous system

A Pavlou, F Mulenge, OL Gern, LM Busker… - Cellular & Molecular …, 2024 - nature.com
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring
viral encephalitis as a global research priority. Upon entry of the virus into the CNS, severe …

Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

R Dey, B Bishayi - Cellular and Molecular Neurobiology, 2024 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is primarily a respiratory disease causing a
worldwide pandemic in the year of 2019. SARS‐CoV‐2 is an enveloped, positive-stranded …

Direct and indirect impact of SARS-CoV-2 on the brain

JPS Peron - Human Genetics, 2023 - Springer
Although COVID-19 is mostly a pulmonary disease, it is now well accepted that it can cause
a much broader spectrum of signs and symptoms and affect many other organs and tissue …

[HTML][HTML] Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine …

S Ravichandran, N Manickam, M Kandasamy - Medicine in Drug Discovery, 2022 - Elsevier
The emergence of new SARS-CoV-2 variants continues to pose an enormous public health
concern. The SARS-CoV-2 infection disrupted host immune response accounting for …

Zika virus infection induces interleukin-1β-mediated inflammatory responses by macrophages in the brain of an adult mouse model

GU Jeong, S Lee, DY Kim, J Lyu, GY Yoon… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT During the 2015–2016 Zika virus (ZIKV) epidemic, ZIKV-associated
neurological diseases were reported in adults, including microcephaly, Guillain-Barre …

Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings

ACE Granholm, E Englund, A Gilmore, E Head… - Acta …, 2024 - Springer
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting
neurologic symptoms in many patients, with an increased mortality risk for people with …

Exploring viral neuropathic pain: Molecular mechanisms and therapeutic implications

S Xu, H Li, Z Ai, R Guo, H Cheng, Y Wang - Plos Pathogens, 2024 - journals.plos.org
As the Coronavirus Disease 2019 (COVID-19) pandemic continues, there is a growing
concern regarding the relationship between viral infections and neuropathic pain. Chronic …

Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …

Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins

JCS Chaves, LA Milton, R Stewart, T Senapati… - Journal of Neuroimmune …, 2024 - Springer
SARS-CoV-2 spike proteins have been shown to cross the blood–brain barrier (BBB) in
mice and affect the integrity of human BBB cell models. However, the effects of SARS-CoV-2 …