Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in
cancer development. Since the discovery of the identity and clinical functions of miRNAs …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …

Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …