This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

This review summarizes current knowledge about the mechanisms of timely binding and
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …

In Escherichia coli, the replication initiator DnaA oscillates between an ATP-and an ADP-
bound state in a cell cycle-dependent manner, supporting regulation for chromosome …

Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …

Plasmids are autonomously replicating sequences that help cells adapt to diverse stresses.
Theta plasmids are the most frequent plasmid class in enterobacteria. They co-opt two host …

DNA replication is a tightly coordinated event carried out by a multiprotein replication
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …

The homotetrameric DnaD protein is essential in low G+ C content gram positive bacteria
and is involved in replication initiation at oriC and re-start of collapsed replication forks. It …

Propagation of genetic material is central to the survival and fitness of multicellular
organisms. To efficiently duplicate eukaryotic genomes of sizes between∼ 10 7 bp (yeast) …

Sixty years ago, bacterial cell size was found to be an exponential function of growth rate.
Fifty years ago, a more general relationship was proposed, in which cell mass was equal to …

There is an urgent need for new antibiotics to combat drug resistant bacteria. Existing
antibiotics act on only a small number of proteins and pathways in bacterial cells, and it …