The DnaA Cycle in Escherichia coli: Activation, Function and Inactivation of the Initiator Protein
T Katayama, K Kasho, H Kawakami - Frontiers in microbiology, 2017 - frontiersin.org
This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …
IHF and Fis as Escherichia coli Cell Cycle Regulators: Activation of the Replication Origin oriC and the Regulatory Cycle of the DnaA Initiator
K Kasho, S Ozaki, T Katayama - International journal of molecular …, 2023 - mdpi.com
This review summarizes current knowledge about the mechanisms of timely binding and
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …
Negative feedback for DARS2–Fis complex by ATP–DnaA supports the cell cycle-coordinated regulation for chromosome replication
K Miyoshi, Y Tatsumoto, S Ozaki… - Nucleic acids …, 2021 - academic.oup.com
In Escherichia coli, the replication initiator DnaA oscillates between an ATP-and an ADP-
bound state in a cell cycle-dependent manner, supporting regulation for chromosome …
bound state in a cell cycle-dependent manner, supporting regulation for chromosome …
From processivity to genome maintenance: the many roles of sliding clamps
Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
Mechanisms of Theta plasmid replication in Enterobacteria and implications for adaptation to its host
JW Kim, V Bugata, G Cortés-Cortés… - EcoSal plus, 2020 - Am Soc Microbiol
Plasmids are autonomously replicating sequences that help cells adapt to diverse stresses.
Theta plasmids are the most frequent plasmid class in enterobacteria. They co-opt two host …
Theta plasmids are the most frequent plasmid class in enterobacteria. They co-opt two host …
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery
S Simonsen, CK Søgaard, JG Olsen, M Otterlei… - Cellular and Molecular …, 2024 - Springer
DNA replication is a tightly coordinated event carried out by a multiprotein replication
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …
DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA–DnaD interaction
E Martin, HEL Williams, M Pitoulias… - Nucleic acids …, 2019 - academic.oup.com
The homotetrameric DnaD protein is essential in low G+ C content gram positive bacteria
and is involved in replication initiation at oriC and re-start of collapsed replication forks. It …
and is involved in replication initiation at oriC and re-start of collapsed replication forks. It …
A structural view of the initiators for chromosome replication
Propagation of genetic material is central to the survival and fitness of multicellular
organisms. To efficiently duplicate eukaryotic genomes of sizes between∼ 10 7 bp (yeast) …
organisms. To efficiently duplicate eukaryotic genomes of sizes between∼ 10 7 bp (yeast) …
Cell size is coordinated with cell cycle by regulating initiator protein DnaA in E. coli
Sixty years ago, bacterial cell size was found to be an exponential function of growth rate.
Fifty years ago, a more general relationship was proposed, in which cell mass was equal to …
Fifty years ago, a more general relationship was proposed, in which cell mass was equal to …
Targeting the bacterial orisome in the search for new antibiotics
JE Grimwade, AC Leonard - Frontiers in microbiology, 2017 - frontiersin.org
There is an urgent need for new antibiotics to combat drug resistant bacteria. Existing
antibiotics act on only a small number of proteins and pathways in bacterial cells, and it …
antibiotics act on only a small number of proteins and pathways in bacterial cells, and it …