Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …

Phosphatidylinositol 4, 5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require …

Abstract Changes in membrane potential affect ion channels and transporters, which then
alter intracellular chemical conditions. Other signalling pathways coupled to membrane …

The subjective feeling of cold is mediated by the activation of TRPM8 channels in
thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we …

KCNQ channels belong to a family of potassium ion channels with crucial roles in
physiology and disease. Heteromers of KCNQ2/3 subunits constitute the neuronal M …