In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …

Animal cells undergo dramatic changes in shape, mechanics and polarity as they progress
through the different stages of cell division. These changes begin at mitotic entry, with cell …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

This monograph consists of two main parts, mathematical and biological. The mathematical
part, which is quite sophisticated involving advanced asymptotic methods in partial …

A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …

The mitotic checkpoint acts to maintain chromosome content by generation of a diffusible
anaphase inhibitor. Unattached kinetochores catalyze a conformational shift in Mad2 …

The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures
accurate chromosome segregation during cell division. It consists of a mechanochemical …

Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring
faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of …

Variability and Robustness in Biomolecular Systems: Molecular Cell Skip to Main Content
Advertisement Molecular Cell This journal offers authors two options (open access or …

Almost two decades after their identification, the components of the mitotic checkpoint are
finally revealing their structural secrets. The activation of Mad2, a central piece of the …