Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Metabolomics seeks to take a “snapshot” in a time of the levels, activities, regulation and
interactions of all small molecule metabolites in response to a biological system with genetic …

Conspectus In the two decades since mass spectrometry imaging (MSI) was first applied to
visualize the distribution of peptides across biological tissues and cells, the technique has …

Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

In this study we have explored several aspects of regional analyte suppression in mass
spectrometry imaging (MSI) of a heterogeneous sample, transverse cryosections of mouse …

Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Metabolomics has been widely used for investigating the biological functions of disease
expression and has the potential to discover biomarkers in circulating biofluids or tissue …

How do we understand neuronal signaling in the brain, how neurons control behavior, or
how signaling malfunctions during disease? Neuroscientists might take two approaches …