Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is
associated with repetitive head impacts or exposure to blast waves. First described as punch …

Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase …

Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …