The envelope glycoprotein complex of replication competent retroviruses is comprised of
two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane …

Retroviruses are an important group of pathogens that cause a variety of diseases in
humans and animals. Four human retroviruses are currently known, including human …

To establish the phenotype of human T-cell leukemia virus type 1 (HTLV-1)-infected cells in
peripheral blood, the polymerase chain reaction was used to detect and quantitate viral DNA …

Human T-cell leukemia virus type 1 (HTLV-1) immortalizes human CD4+ T lymphocytes in
culture. Previous studies show that in the context of a herpesvirus saimiri vector, the …

We have studied the genetic variation of human T-cell leukemia/lymphoma virus type I
(HTLV-I) isolates in the same individuals over time, as well as of HTLV-I isolates from …

For nearly two decades it has been suspected that the cutaneous T cell lymphoma, mycosis
fungoides (MF), and its leukemic variant, the Sézary syndrome, are caused by the human T …

The tax gene product of human T-cell leukemia virus type I (HTLV-I) is a potent
transcriptional activator that both stimulates viral gene expression and activates an array of …

Three protein isoforms are encoded by the human T-cell leukemia/lymphotropic virus type I
pX region open reading frames (ORF) I and II through alternative splicing. Both the singly …

Recent studies have shown that the p300/CREB binding protein (CBP)-associated factor
(PCAF) is involved in transcriptional activation. PCAF activity has been shown strongly …

Although brain lesions have been described in some cases with HTLV-I-associated
myelopathy/tropical spastic paraparesis (HAM/TSP), little is known about the nature of brain …