Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

Epigenetic modifications play important roles during the pathogenesis of multiple myeloma
(MM). Herein, we found that protein arginine methyltransferase 1 (PRMT1) was highly …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new
therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

Abstract Bromodomain-containing protein 4 (BRD4), the major component of bromodomain
and extra-terminal domain (BET) protein family, has important functions in early embryonic …

Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …

Colorectal cancer (CRC) has a high degree of heterogeneity and identifying the genetic
information of individual tumor cells could help enhance our understanding of tumor biology …

Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various
biological processes. NONO, a central paraspeckle component, has been shown to play …

Tumor metastasis is the leading cause of mortality among advanced cancer patients.
Understanding its mechanisms and treatment strategies is vital for clinical application …