Halofuginone is an analog of febrifugine—an alkaloid originally isolated from the plant
Dichroa febrifuga. During recent years, halofuginone has attracted much attention because …

Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …

Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …

Computational techniques such as structure-based virtual screening require carefully
prepared 3D models of potential small-molecule ligands. Though powerful, existing …

Malaria is one of the most prevailing fatal diseases causing between 1.2 and 2.7 million
deaths all over the world each year. Further, development of resistance against the frontline …

To screen the active antimalarial novel artemisinin derivatives, a QSAR modeling approach
was used. QSAR model showed high correlation (r2= 0.83 and rCV2= 0.81) and indicated …

Parkinson's disease is a neurological illness that slowly impairs a small number of neurons
in the substantia nigra, a part of the brain. Dopamine, a substance (neurotransmitter) that …

Bruton's tyrosine Kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase expressed in
hematopoietic cells. BTK plays a critical role in many cellular signalling pathways making it a …

To discover new acetyl-CoA carboxylase (ACCase) inhibiting-based herbicides, twenty-nine
novel quinazolin-4 (3 H)-one derivatives were designed and synthesized based on the …

Glucose transporter 1 (GLUT1) plays an important role in the transport of glucose into cells.
Studies found that GLUT1 is highly expressed in a variety of tumor cells, and it's the rate …