Simple Summary Due to the lack of selectivity and the severe side-effects, cytostatics are the
drugs of the present but not of the future and consequently new anticancer strategies must …

Tachykinins (TKs) include an evolutionarily conserved group of small bio-active peptides
which possess a common carboxyl-terminal sequence, Phe-X-Gly-Leu-Met-NH2. TKs also …

Background Numerous molecules have been introduced to participate in the formation of
breast cancer, the most common malignancy in women. Among them, neuropeptide …

Aims Prostate cancer continues to be one of the main global health issues in men.
Neuropeptide substance P (SP) acting via neurokinin-1receptor (NK1R) promotes …

Background. Colorectal cancer (CRC) is recognized as one of the most common
malignancies with a high mortality rate worldwide, supporting the necessity for an effective …

Background Cervical cancer, an aggressive gynecological cancer, seriously threatens
women's health worldwide. It is recently reported that neuropeptide substance P (SP) …

One of the most prevalent malignancies is esophageal squamous cell carcinoma (ESCC),
which is associated with high morbidity and mortality. Substance P (SP), as one of the …

Tachykinins such as Substance P (SP) are a group of neuropeptides that are involved in
cancer development. Neurokinin-1 receptor (NK-1R) is the main tachykinin receptor …

The antagonists of the neurokinin‐1 receptor (NK1R) are known for their anti‐inflammatory,
anxiolytic, antiemetic, and anticancer activities. Aprepitant, a nonpeptide NK1R antagonist …

Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic
protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide …