Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Eye pain is an unpleasant sensory and emotional experience including sensory-
discriminative, emotional, cognitive, and behavioral components and supported by distinct …

We examined the relation between ectopic afferent firing and tactile allodynia in the Chung
model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four …

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …

Pain is a major symptom of many different diseases. Modern pain research has uncovered
important neuronal mechanisms that are underlying clinically relevant pain states, and …

Pain research has uncovered important neuronal mechanisms that underlie clinically
relevant pain states such as inflammatory and neuropathic pain. Importantly, both the …

Neuropathic pain after nerve injury is severe and intractable, and current drugs and nondrug
therapies offer substantial pain relief to no more than half of affected patients. The present …

Ectopic discharge generated in injured afferent axons and cell somata in vivo contributes
significantly to chronic neuropathic dysesthesia and pain after nerve trauma. Progress has …