Vascular dementia is the second most common type of dementia. The subcortical ischaemic
form (SIVD) frequently causes cognitive impairment and dementia in elderly people. SIVD …

Background—The pathogenesis of and relationship between small deep (lacunar) infarcts,
cerebral white matter disease (leukoaraiosis or white matter hyperintensities), and …

Patients with cerebral small vessel disease (SVD) can present as isolated lacunar infarction
or with diffuse white matter changes, with the imaging appearance of leukoaraiosis …

Ischemic stroke is thought to have a polygenic basis, but identification of stroke susceptibility
genes and quantification of associated risks have been hampered by conflicting results from …

Ischaemic stroke can be caused by a number of monogenic disorders, and in such cases
stroke is frequently part of a multisystem disorder. Cerebral autosomal dominant arteriopathy …

The objective of this study was to assess the influence of the ACE gene insertion (I)/deletion
(D) polymorphism on plasma ACE activity; blood pressure; and risk of myocardial infarction …

Objective This meta-analysis attempted to derive pooled estimates for the associations
between various cardiovascular-renal disorders and the deletion/insertion (D/I) …

Lacunar infarcts and “hypertensive” primary intracerebral hemorrhages, collectively often
referred to as hypertensive small vessel strokes, constitute about one third of all strokes …

Background and Purpose—Twin and family history studies support a role for genetic factors
in stroke risk. Because the etiology of ischemic stroke is heterogeneous, genetic factors may …

Background—It is estimated that about half of cardiovascular disease risk is explained by
conventional risk factors. The realization that atherosclerosis is an inflammatory disease has …