Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified
cilium filled with hundreds of flattened 'disc'membranes that provide vast light-absorbing …

Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven
important in not only the development of translational therapeutic approaches, but also in …

Mutations in the photoreceptor-specific C2orf71 gene (also known as photoreceptor cilium
actin regulator protein PCARE) cause autosomal recessive retinitis pigmentosa type 54 and …

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. However, the
pathogenesis and molecular mechanisms underlying ROP remain elusive. Herein, using the …

Cyclic nucleotide-gated (CNG) channels play a central role in rod and cone photoreceptors
of the vertebrate retina. In photoreceptors, light triggers a series of biochemical reactions that …

The rod and cone photoreceptor cells of the vertebrate retina have highly specialized
structures that enable them to carry out their function of light detection over a broad range of …