A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives

SR Brishty, MJ Hossain, MU Khandaker… - Frontiers in …, 2021 - frontiersin.org
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …

Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Antimicrobial evaluation and docking study of some new substituted benzimidazole-2yl derivatives

M Abdel-Motaal, K Almohawes, MA Tantawy - Bioorganic Chemistry, 2020 - Elsevier
Benzimidazoles incorporated biologically active heterocycles such as quinoline, triazine-3-
thione, thiazole and thiadiazole, were synthesized utilizing 2-acetylbenzimidazole as a …

Synthesis and AChE-inhibitory activity of new benzimidazole derivatives

U Acar Cevik, BN Saglik, S Levent, D Osmaniye… - Molecules, 2019 - mdpi.com
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and
degenerative neurological disorder characterized by loss of cognition and memory …

Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease

N Faydalı, ÖT Arpacı - Chemistry & Biodiversity, 2024 - Wiley Online Library
Benzimidazole and benzoxazole derivatives are included in the category of medical drugs in
a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti …

Benzimidazole derivatives in identifying novel acetylcholinesterase inhibitors: a combination of 3D-QSAR, docking and molecular dynamics simulation

K El Khatabi, R El-mernissi, I Aanouz… - Physical Chemistry …, 2022 - physchemres.org
Acetylcholinesterase is a promising therapeutic candidate for the treatment of
neurodegenerative disorders, acetylcholine dysfunction and other cognitive problems. In the …

Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease

KT Shukur, T Ercetin, C Luise, W Sippl… - Archiv der …, 2021 - Wiley Online Library
A series of urolithin amide (ie, URO‐4–URO‐10 and THU‐4–THU‐10) derivatives was
designed and synthesized, and their chemical structures were confirmed with spectroscopic …

Benzimidazole-derived compounds designed for different targets of Alzheimer's disease

HO Gulcan, A Mavideniz, MF Sahin… - Current Medicinal …, 2019 - ingentaconnect.com
Benzimidazole scaffold has been efficiently used for the design of various pharmacologically
active molecules. Indeed, there are various benzimidazole drugs, available today, employed …

[HTML][HTML] Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer's …

MC Rosales Hernández, M Olvera-Valdez… - Molecules, 2024 - mdpi.com
Despite the great effort that has gone into developing new molecules as multitarget
compounds to treat Alzheimer's disease (AD), none of these have been approved to treat …

Formulating the structural aspects of various benzimidazole cognates

PR Krishnendu, VP Koyiparambath… - Current Topics in …, 2022 - benthamdirect.com
Background: Benzimidazole derivatives are widely used in clinical practice as potential
beneficial specialists. Recently, the neuroprotective effect of derivatives of benzimidazole …