Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Ribosomes are cellular machines essential for protein synthesis. The biogenesis of
ribosomes is a highly complex and energy consuming process that initiates in the nucleolus …

Defects in ribosome biogenesis are associated with a group of diseases called the
ribosomopathies, of which Diamond-Blackfan anemia (DBA) is the most studied. Ribosomes …

Autophagy, an ancient and highly conserved intracellular degradation process, is viewed as
a critical component of innate immunity because of its ability to deliver cytosolic bacteria to …

Macroautophagy/autophagy is a key catabolic process, essential for maintaining cellular
homeostasis and survival through the removal and recycling of unwanted cellular material …

The development of a functional vasculature requires the coordinated control of cell fate,
lineage differentiation and network growth. Cellular proliferation is spatiotemporally …

Neurodegenerative diseases affect millions of people worldwide, yet there are currently no
effective treatments. Because risk of neurodegenerative disease substantially increases with …

Autophagy represents a conserved self-digestion program, which allows regulated
degradation of cellular material. Autophagy is activated by cellular stress, serum starvation …

Autophagy, a highly regulated self-degradation process of eukaryotic cells, is a context-
dependent tumor-suppressing mechanism that can also promote tumor cell survival upon …