Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …

Since the turn of the millenium, RNA-based control of gene expression has added an extra
dimension to the central dogma of molecular biology. Still, the roles of Mycobacterium …

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the
various nutrients available during its life cycle. However, in the nutritionally stringent …

Little is known about the decisions behind transcription elongation versus termination in the
human pathogen Mycobacterium tuberculosis (M. TB). By applying Term-seq to M. TB we …

The acquisition of antibiotics resistance is a major clinical challenge limiting the effective
prevention and treatment of the deadliest human infectious disease tuberculosis. The …

The riboflavin biosynthetic pathway is a promising target for the development of novel
antimycobacterial drugs given the lack of riboflavin transporter in M. tuberculosis. Herein, a …

Persistence of mycobacteria in the hostile environment of human macrophage is pivotal for
its successful pathogenesis. Rapid adaptation to diverse stresses is the key aspect for their …

Objectives Identification and validation of novel therapeutic targets is imperative to tackle the
rise of drug resistance in tuberculosis. An essential Mur ligase-like gene (Rv3712), expected …

Abstract Background While Mycobacterium tuberculosis complex (MTBC) variants are
clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis infects many …

Gene expression is tightly controlled by transcription factors and RNA regulatory elements,
including trans‐acting small RNAs, cis‐regulatory riboswitches and ribosome‐dependent …