Lipid peroxidation underlies the mechanism of oxidative cell death now known as
ferroptosis. This modality, distinct from other forms of cell death, has been intensely …

Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

The clinical efficacy of existing cancer therapies is still far from satisfactory. There is an
urgent need to integrate the emerging biomedical discovery and technological innovation …

Background Metabolic reprograming, non-mutational epigenetic changes, increased cell
plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this …

The brain tumor is a kind of malignant tumor with brutal treatment, high recurrence rate, and
poor prognosis, and the incidence and death rate is increasing yearly. Surgery is often used …

The rate-determining step in free radical lipid peroxidation is the propagation of the peroxyl
radical, where generally two types of reactions occur:(a) hydrogen-atom transfer (HAT) from …

Currently, cancer remains one of the most significant threats to human health. Treatment of
most cancers remains challenging, despite the implementation of diverse therapies in …

Regulated cell necrosis supports immune and anti-infectious strategies of the body;
however, dysregulation of these processes drives pathological organ damage …

In contrast to canonical ferroptosis inducers, highly peroxidable conjugated linolenic acids
(CLnA) directly fuel the lipid peroxidation cascade upon their incorporation into membrane …