Oxidative stress has a critical role in the pathophysiology of several kidney diseases, and
many complications of these diseases are mediated by oxidative stress, oxidative stress …

Oxidative stress is a major mediator of adverse outcomes throughout the course of
transplantation. Transplanted kidneys are prone to oxidative stress-mediated injury by pre …

This article examines the actions of taurine on models of renal dysfunction, the potential
mechanisms of taurine action and the possible clinical significance of these findings. Our …

WHAT IS ALREADY KNOWN ABOUT THE SUBJECT• Ciclosporin's nephrotoxicity initially
targets the proximal tubule and is, at least in part, driven by increased formation of oxygen …

Calcineurin inhibitor nephrotoxicity, especially for the widely used tacrolimus, has become a
major concern in post‐transplant immunosuppression. Multiparametric amino acid …

Organ transplantation is the treatment of choice for many end stage diseases. The
development and appropriate use of new immunosupressants have considerably improved …

Background Previous studies have examined and documented fluctuations in urine
metabolites in response to disease processes and drug toxicity affecting glomerular filtration …

Introduction: A major challenge in transplantation is improving long-term organ transplant
and patient survival. Immunosuppressants protect the transplant organ from alloimmune …

The improvement of long‐term transplant organ and patient survival remains a critical
challenge following kidney transplantation. Proteomics and biochemical profiling …

The basic mechanisms underlying calcineurin inhibitor (CI) nephrotoxicity and its
enhancement by sirolimus are still largely unknown. We investigated the effects of CIs alone …