Induction of oxidative stress in kidney
E Ozbek - International journal of nephrology, 2012 - Wiley Online Library
Oxidative stress has a critical role in the pathophysiology of several kidney diseases, and
many complications of these diseases are mediated by oxidative stress, oxidative stress …
many complications of these diseases are mediated by oxidative stress, oxidative stress …
Oxidative stress in kidney transplantation: causes, consequences, and potential treatment.
Oxidative stress is a major mediator of adverse outcomes throughout the course of
transplantation. Transplanted kidneys are prone to oxidative stress-mediated injury by pre …
transplantation. Transplanted kidneys are prone to oxidative stress-mediated injury by pre …
The role of taurine in renal disorders
X Han, RW Chesney - Amino acids, 2012 - Springer
This article examines the actions of taurine on models of renal dysfunction, the potential
mechanisms of taurine action and the possible clinical significance of these findings. Our …
mechanisms of taurine action and the possible clinical significance of these findings. Our …
Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose
J Klawitter, M Haschke, C Kahle… - British journal of …, 2010 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THE SUBJECT• Ciclosporin's nephrotoxicity initially
targets the proximal tubule and is, at least in part, driven by increased formation of oxygen …
targets the proximal tubule and is, at least in part, driven by increased formation of oxygen …
Targeted metabolomic analysis of 33 amino acids and biogenic amines in human urine by ion‐pairing HPLC‐MS/MS: Biomarkers for tacrolimus nephrotoxicity after …
T Xia, S Fu, Q Wang, Y Wen, S Chan… - Biomedical …, 2018 - Wiley Online Library
Calcineurin inhibitor nephrotoxicity, especially for the widely used tacrolimus, has become a
major concern in post‐transplant immunosuppression. Multiparametric amino acid …
major concern in post‐transplant immunosuppression. Multiparametric amino acid …
Metabolomics: Perspectives on potential biomarkers in organ transplantation and immunosuppressant toxicity
E Bonneau, N Tétreault, R Robitaille, A Boucher… - Clinical …, 2016 - Elsevier
Organ transplantation is the treatment of choice for many end stage diseases. The
development and appropriate use of new immunosupressants have considerably improved …
development and appropriate use of new immunosupressants have considerably improved …
A high-performance liquid chromatography–tandem mass spectrometry–based targeted metabolomics kidney dysfunction marker panel in human urine
J Klepacki, J Klawitter, J Klawitter, JM Thurman… - Clinica Chimica …, 2015 - Elsevier
Background Previous studies have examined and documented fluctuations in urine
metabolites in response to disease processes and drug toxicity affecting glomerular filtration …
metabolites in response to disease processes and drug toxicity affecting glomerular filtration …
Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions
U Christians, J Klawitter, J Klawitter… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: A major challenge in transplantation is improving long-term organ transplant
and patient survival. Immunosuppressants protect the transplant organ from alloimmune …
and patient survival. Immunosuppressants protect the transplant organ from alloimmune …
Proteomics and metabolomics in renal transplantation‐quo vadis?
R Bohra, J Klepacki, J Klawitter, J Klawitter… - Transplant …, 2013 - Wiley Online Library
The improvement of long‐term transplant organ and patient survival remains a critical
challenge following kidney transplantation. Proteomics and biochemical profiling …
challenge following kidney transplantation. Proteomics and biochemical profiling …
Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study
J Klawitter, J Klawitter, E Kushner… - Journal of Proteome …, 2010 - ACS Publications
The basic mechanisms underlying calcineurin inhibitor (CI) nephrotoxicity and its
enhancement by sirolimus are still largely unknown. We investigated the effects of CIs alone …
enhancement by sirolimus are still largely unknown. We investigated the effects of CIs alone …