Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers
through methylation and molecular rearrangement. These functions take place in fatty acid …

Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …

Background Remethylation defects are rare inherited disorders in which impaired
remethylation of homocysteine to methionine leads to accumulation of homocysteine and …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Combined methylmalonic acidemia and homocystinuria, cblC type, is an inborn error of
intracellular cobalamin metabolism with a wide spectrum of clinical manifestations that is …

The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility,
supporting both methyl transfer and isomerization reactions. During evolution of higher …

The haematological and neurological consequences of cobalamin deficiency define the
essential role of this vitamin in key metabolic reactions. The identification of cubilin …