Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

The development of a drug-resistant cell line can take from 3 to 18 months. However, little is
published on the methodology of this development process. This article will discuss key …

BACKGROUND Compelling evidence indicates that paclitaxel kills cancer cells through the
induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression …

While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

Microtubules are highly dynamic cellular polymers made of αβ-tubulin and associated
proteins. They play a key role during mitosis, participating in the exact organization and …

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine
anticancer drugs with different modes of action to avoid the development of resistance did …

DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce
mutations, chromosomal rearrangements and cell death. Inducers of ICLs are important …