[HTML][HTML] Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds

MMK Amer, MA Aziz, WS Shehab, MH Abdellattif… - Journal of Saudi …, 2021 - Elsevier
Background The chemistry and applications of 2-pyridone structures have recently attracted
a lot of attention due to their uses as synthetic intermediates and their biological importance …

Fundamental basis for implementing oxidant‐free Au (I)/Au (III) catalysis

P Font, X Ribas - European Journal of Inorganic Chemistry, 2021 - Wiley Online Library
Abstract Oxidant‐free Au (I)/Au (III) catalysis can still be regarded as a young and promising
chemistry. Because the first examples of gold catalysis were limited to the activation and …

Calcium (II)-catalyzed intra-and intermolecular hydroamidation of unactivated alkenes in hexafluoroisopropanol

C Qi, F Hasenmaile, V Gandon, D Leboeuf - ACS Catalysis, 2018 - ACS Publications
A combination of a calcium (II) triflimide salt and hexafluoroisopropanol (HFIP) was found to
be a highly efficient promoter system for the intra-and intermolecular hydroamidation of …

[HTML][HTML] Gold-catalyzed homogeneous (cyclo) isomerization reactions

M Marín-Luna, O Nieto Faza, C Silva López - Frontiers in Chemistry, 2019 - frontiersin.org
Gold is currently one of the most used metals in organometallic catalysis. The ability of gold
to activate unsaturated groups in different modes, together with its tolerance to a wide range …

Origin of the anti-Markovnikov hydroamination of alkenes catalyzed by L–Au (I) complexes: coordination mode determines regioselectivity

A Couce-Rios, A Lledos, I Fernandez, G Ujaque - ACS Catalysis, 2018 - ACS Publications
The reaction mechanism and regioselectivity for the gold (I)-catalyzed hydroamination
reaction of terminal alkenes are analyzed by means of density functional theory (DFT) …

Pyridones–powerful precursors for the synthesis of Alkaloids, their derivatives, and alkaloid-inspired compounds

JG Sośnicki, TJ Idzik - Synthesis, 2019 - thieme-connect.com
2-Pyridone is characterized by a very wide range of reactivity of a different nature, ranging
from electrophilic aromatic substitution, CH–metal-mediated reactions, and NH/OH …

Highly Regioselective Synthesis of N‐β‐trifluoromethyl 2‐pyridones via anti‐Markovnikov Hydroamination of α‐(trifluoromethyl)styrenes with 2‐pyridones

Y Zhang, Z Sun, J He, Y Deng, Y Liu… - Chemistry–An Asian …, 2023 - Wiley Online Library
A novel and facile method for the synthesis of N‐β‐CF3‐substituted 2‐pyridones via
hydroamination of α‐(trifluoromethyl) styrenes with 2‐pyridones was described. The reaction …

Regioselective N‐Functionalization of Tautomerizable Heterocycles through Methyl Trifluoromethanesulfonate‐Catalyzed Substitution of Alcohols and Alkyl Group …

S Duari, S Biswas, A Roy, S Maity… - Advanced Synthesis …, 2022 - Wiley Online Library
A catalytic synthetic strategy has been developed combining two protocols, such as, direct
nucleophilic substitution of alcohols followed by X‐to N‐alkyl group migration (X= O, S) to …

A gold (I)-catalyzed hydroamination/cycloisomerization cascade: Concise synthesis of (±)-seco-antofine and (±)-septicine

G Tian, L Song, Z Li, K Robeyns, L Van Meervelt… - Organic …, 2020 - ACS Publications
A concise and flexible procedure for the synthesis of highly functionalized N-heterocyclic 1,
6-annulated 2-pyridones and 2, 3-annulated 4-pyrimidinones has been elaborated through …

N-alkylation of 2-pyridone derivatives via palladium (II)-catalyzed directed alkene hydroamination

JA Gurak Jr, VT Tran, MM Sroda, KM Engle - Tetrahedron, 2017 - Elsevier
A selective N-alkylation reaction of 2-pyridones and related heterocycles via intermolecular
alkene hydroamination is reported. The reaction utilizes palladium (II) acetate as a catalyst …