[HTML][HTML] Pancreatic β-cell proliferation in obesity

AK Linnemann, M Baan, DB Davis - Advances in nutrition, 2014 - Elsevier
Because obesity rates have increased dramatically over the past 3 decades, type 2 diabetes
has become increasingly prevalent as well. Type 2 diabetes is associated with decreased …

[HTML][HTML] Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

IM Akcay, S Katrinli, K Ozdil, GD Doganay… - World journal of …, 2018 - ncbi.nlm.nih.gov
The clinical outcome of hepatitis B virus (HBV) infection depends on the success or failure of
the immune responses to HBV, and varies widely among individuals, ranging from …

Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma

F Rossi, I Legnini, F Megiorni, A Colantoni, T Santini… - Oncogene, 2019 - nature.com
Circular RNAs (circRNAs) represent a class of covalently closed RNAs, derived from non-
canonical splicing events, which are expressed in all eukaryotes and often conserved …

Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

IM Echevarría‐Vargas, PI Reyes‐Uribe… - EMBO molecular …, 2018 - embopress.org
Despite novel therapies for melanoma, drug resistance remains a significant hurdle to
achieving optimal responses. NRAS‐mutant melanoma is an archetype of therapeutic …

[HTML][HTML] COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types

BJ Schmiedel, J Rocha, C Gonzalez-Colin… - Nature …, 2021 - nature.com
Common genetic polymorphisms associated with COVID-19 illness can be utilized for
discovering molecular pathways and cell types driving disease pathogenesis. Given the …

[HTML][HTML] Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

FK Ndiaye, A Ortalli, M Canouil, M Huyvaert… - Molecular …, 2017 - Elsevier
Objectives Genome-wide association studies (GWAS) have identified> 100 loci
independently contributing to type 2 diabetes (T2D) risk. However, translational implications …

Autophagy stimulation abrogates herpes simplex virus-1 infection

AM Yakoub, D Shukla - Scientific Reports, 2015 - nature.com
Abstract Herpes simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-
long infections. HSV-1 infections may lead to herpetic stromal keratitis that may advance to …

TCF19 promotes cell proliferation through binding to the histone H3K4me3 mark

P Mondal, S Sen, BJ Klein, N Tiwary, SS Gadad… - Biochemistry, 2019 - ACS Publications
Transcription factor 19 (TCF19) plays critical roles in type 1 diabetes and the maintenance of
pancreatic β cells. Recent studies have also implicated TCF19 in cell proliferation of hepatic …

TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation

P Mondal, SS Gadad, S Adhikari, EI Ramos… - The FASEB …, 2021 - Wiley Online Library
Alteration in glucose homeostasis during cancer metabolism is an important phenomenon.
Though several important transcription factors have been well studied in the context of the …

[HTML][HTML] Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers

GM Gilligan, RL Panico, C Di Tada… - … Oral, Patología Oral y …, 2020 - ncbi.nlm.nih.gov
Background Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers
(CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in …