The application of deep learning in cancer prognosis prediction

W Zhu, L Xie, J Han, X Guo - Cancers, 2020 - mdpi.com
Deep learning has been applied to many areas in health care, including imaging diagnosis,
digital pathology, prediction of hospital admission, drug design, classification of cancer and …

Deep learning in cancer diagnosis and prognosis prediction: a minireview on challenges, recent trends, and future directions

AB Tufail, YK Ma, MKA Kaabar… - … Methods in Medicine, 2021 - Wiley Online Library
Deep learning (DL) is a branch of machine learning and artificial intelligence that has been
applied to many areas in different domains such as health care and drug design. Cancer …

Cox-nnet: an artificial neural network method for prognosis prediction of high-throughput omics data

T Ching, X Zhu, LX Garmire - PLoS computational biology, 2018 - journals.plos.org
Artificial neural networks (ANN) are computing architectures with many interconnections of
simple neural-inspired computing elements, and have been applied to biomedical fields …

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

W Yang, Y Xia, H Ji, Y Zheng, J Liang, W Huang, X Gao… - Nature, 2011 - nature.com
The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In
contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect,,, its non …

Recent advances in the molecular understanding of glioblastoma

FE Bleeker, RJ Molenaar, S Leenstra - Journal of neuro-oncology, 2012 - Springer
Glioblastoma is the most common and most aggressive primary brain tumor. Despite
maximum treatment, patients only have a median survival time of 15 months, because of the …

Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology

LAM Gravendeel, MCM Kouwenhoven, O Gevaert… - Cancer research, 2009 - AACR
Gliomas are the most common primary brain tumors with heterogeneous morphology and
variable prognosis. Treatment decisions in patients rely mainly on histologic classification …

Long non-coding RNA expression profiles predict clinical phenotypes in glioma

X Zhang, S Sun, JKS Pu, ACO Tsang, D Lee… - Neurobiology of …, 2012 - Elsevier
Glioma is the commonest form of primary brain tumor in adults with varying malignancy
grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of …

Multi-omics analysis: Paving the path toward achieving precision medicine in cancer treatment and immuno-oncology

V Raufaste-Cazavieille, R Santiago… - Frontiers in Molecular …, 2022 - frontiersin.org
The acceleration of large-scale sequencing and the progress in high-throughput
computational analyses, defined as omics, was a hallmark for the comprehension of the …

An introduction to artificial neural networks in bioinformatics—application to complex microarray and mass spectrometry datasets in cancer studies

LJ Lancashire, C Lemetre, GR Ball - Briefings in bioinformatics, 2009 - academic.oup.com
Applications of genomic and proteomic technologies have seen a major increase, resulting
in an explosion in the amount of highly dimensional and complex data being generated …

Glioma IL13Rα2 is associated with mesenchymal signature gene expression and poor patient prognosis

CE Brown, CD Warden, R Starr, X Deng, B Badie… - PloS one, 2013 - journals.plos.org
A major challenge for successful immunotherapy against glioma is the identification and
characterization of validated targets. We have taken a bioinformatics approach towards …