Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

The concept of bioisosterism and the implementation of bioisosteric replacement is
fundamental to medicinal chemistry. The exploration of bioisosteres is often used to probe …

Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …

There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …

Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and
have been demonstrated to be very successful in combating viral infections in clinic …

Heterocyclic compounds play a critical role in medicinal chemistry, and many available
drugs contain heterocyclic rings. A six-membered heterocyclic compound, pyridine, showed …

In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

The mechanisms involved in programmed or damage-induced removal of mitochondria by
mitophagy remains elusive. Here, we have screened for regulators of PRKN-independent …

Ebola Virus Disease (EVD) is one of the most lethal transmissible infections, characterized
by a high fatality rate, and caused by a member of the Filoviridae family. The recent large …