Cancer is a major public health problem around the world. Currently, about 5% of women
diagnosed with cancer are of reproductive age. These young survivors may face …

The clinical use of doxorubicin in cancer is limited by cardiotoxic effects that can lead to
heart failure. Whereas earlier work focused on the direct impact of doxorubicin on …

Chemotherapy was conventionally applied to kill cancer cells, but regrettably, they also
induce damage to normal cells with high-proliferative capacity resulting in cardiotoxicity …

Recent strides in anti-cancer therapeutics have improved longevity and led to a growing
population of cancer survivors, who are increasingly likely to die of other causes. Treatment …

Background The risk of thrombotic complications such as deep vein thrombosis (DVT)
during tumor development is well known. Tumors release into the circulation procoagulant …

Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic
drugs on the ovary have opened up new directions for the protection of the ovary from …

As the incidence of malignancies in young adults is increasing, fertility preservation in
cancer survivors arises as a major concern. Especially among female cancer patients …

STUDY QUESTION Is ceramide-1-phosphate (C1P) an ovarian protective agent during
alkylating chemotherapy? SUMMARY ANSWER Local administration of C1P drastically …

Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and
subsequent infertility. In order to protect gametes from the gonadotoxic effects of …

Ovarian follicle pool depletion, infertility, and premature menopause are all known sequelae
of cancer treatment that negatively impact the quality of life of young cancer survivors. The …