[HTML][HTML] Early human embryonic development: Blastocyst formation to gastrulation
J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders
S Bizzotto, CA Walsh - Nature Reviews Neuroscience, 2022 - nature.com
Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …
genome starting from the first postzygotic cell generation and continuing throughout the …
[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
[HTML][HTML] De novo detection of somatic mutations in high-throughput single-cell profiling data sets
Abstract Characterization of somatic mutations at single-cell resolution is essential to study
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …
[HTML][HTML] Deciphering cell states and genealogies of human haematopoiesis
The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
[HTML][HTML] Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease
Gene therapy (GT) provides a potentially curative treatment option for patients with sickle
cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials …
cell disease (SCD); however, the occurrence of myeloid malignancies in GT clinical trials …
Recent advances in single-cell sequencing technologies
L Wen, F Tang - Precision clinical medicine, 2022 - academic.oup.com
Single-cell omics sequencing was first achieved for the transcriptome in 2009, which was
followed by fast development of technologies for profiling the genome, DNA methylome, 3D …
followed by fast development of technologies for profiling the genome, DNA methylome, 3D …
The evolution of two transmissible cancers in Tasmanian devils
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …
tumor 1 (DFT1) and devil facial tumor 2 (DFT2). We investigated the genetic diversity and …
Cellular barcoding to decipher clonal dynamics in disease
Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution
Mitochondria (MT) participate in most metabolic activities of mammalian cells. A near-
unidirectional mitochondrial transfer from T cells to cancer cells was recently observed to" …
unidirectional mitochondrial transfer from T cells to cancer cells was recently observed to" …