This narrative review addresses the definition of acute‐on‐chronic liver failure, a condition
associated with high short‐term mortality in patients with chronic liver disease and/or …

Liver disease poses a substantial burden in Latin America. This burden is primarily
attributed to a high level of alcohol consumption and the increasing prevalence of risk …

Background & Aims The prognostic impact of acute decompensation (AD), ie the
development of complications that require hospitalization, has recently been assessed …

Background Patient heterogeneity poses significant challenges for managing individuals
and designing clinical trials, especially in complex diseases. Existing classifications rely on …

The progression of cirrhosis with clinically significant portal hypertension towards
decompensated cirrhosis remains clinically challenging and the evolution towards acute-on …

It is essential to identify the subgroup of patients who experience poorer outcomes in order
to adapt clinical management effectively. In the context of liver disease, the earlier the …

Patient heterogeneity represents a significant challenge for both individual patient
management and clinical trial design, especially in the context of complex diseases. Most …

Background and aims In patients with acutely decompensated cirrhosis (ADC) who present
with clinically apparent precipitants (ie, infections, acute liver injury), alterations in blood …

Acute-on-chronic liver failure (ACLF), usually precipitated by alcohol misuse or viral
reactivation, is a rapid onset and usually reversible liver failure. There have been various …

Purpose: Acute-on-chronic liver failure (ACLF) is a leading cause of death in cirrhotic
patients. This study aims to describe the outcomes of in-patients with ACLF at a liver …