Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target
Abstract Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of
tumour cells and tumour tissues derived from human breast, colorectum, stomach …
tumour cells and tumour tissues derived from human breast, colorectum, stomach …
[HTML][HTML] STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma
K Jiang, X Yin, Q Zhang, J Yin, Q Tang, M Xu, L Wu… - Redox biology, 2023 - Elsevier
Radioresistance is the major reason for the failure of radiotherapy in esophageal squamous
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …
The significance of Stanniocalcin 2 in malignancies and mechanisms
S Li, Q Huang, D Li, L Lv, Y Li, Z Wu - Bioengineered, 2021 - Taylor & Francis
ABSTRACT Human stanniocalcin 2 (STC2) is an ortholog of fish stanniocalcins (STCs) and
is widely expressed in various organs and tissues. The gene is localized on chromosome …
is widely expressed in various organs and tissues. The gene is localized on chromosome …
Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer
YN Liu, MF Tsai, SG Wu, TH Chang… - … Journal of Cancer, 2019 - Wiley Online Library
Constitutive activation of the epidermal growth factor receptor (EGFR) signaling pathway is
implicated in the initiation and progression of lung cancer. EGFR tyrosine kinase inhibitor …
implicated in the initiation and progression of lung cancer. EGFR tyrosine kinase inhibitor …
[HTML][HTML] Deregulated expression of HDAC3 in colorectal cancer and its clinical significance
Background. To date, 4 classes of histone deacetylases (HDACs) have been identified in
humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include …
humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include …
Effect of STC2 gene silencing on colorectal cancer cells
Q Li, X Zhou, Z Fang, Z Pan - Molecular medicine …, 2019 - spandidos-publications.com
Abstract Stanniocalcin 2 (STC2), a secretory glycoprotein hormone, regulates many
biological processes including cell proliferation, apoptosis, tumorigenesis and …
biological processes including cell proliferation, apoptosis, tumorigenesis and …
Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer
K Yokoi, K Yamashita, S Ishii, T Tanaka… - British journal of …, 2017 - nature.com
Background: Neoadjuvant chemoradiotherapy (NCRT) for advanced rectal cancer (RC) is a
well-evidenced therapy; however, some RC patients have no therapeutic response. Patient …
well-evidenced therapy; however, some RC patients have no therapeutic response. Patient …
Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans
Background Antipsychotic (AP) medications are the first line of treatment for schizophrenia.
However, most conferr a risk of antipsychotic-induced weight gain (AIWG). The objective of …
However, most conferr a risk of antipsychotic-induced weight gain (AIWG). The objective of …
Stanniocalcin 2 induces oxaliplatin resistance in colorectal cancer cells by upregulating P-glycoprotein
Q Yuan, L Zhan, LL Zhang, Q Wang… - Canadian journal of …, 2016 - cdnsciencepub.com
Multidrug resistance (MDR) limits the anticancer effects of chemotherapy in patients with
metastatic colorectal cancer (CRC). Oxaliplatin is a common component of combinational …
metastatic colorectal cancer (CRC). Oxaliplatin is a common component of combinational …
Identifying a Risk Signature of Methylation-Driven Genes as a Predictor of Survival Outcome for Colon Cancer Patients
B Zhao, J Wang, G Sheng, Y Wang, T Yang… - Applied Biochemistry and …, 2024 - Springer
Aberrant expression of gene is driven by its promoter methylation and is the key molecular
basis of carcinogenic processes. This study aimed at identifying a risk signature of …
basis of carcinogenic processes. This study aimed at identifying a risk signature of …