Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target

S Qie, N Sang - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Abstract Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of
tumour cells and tumour tissues derived from human breast, colorectum, stomach …

[HTML][HTML] STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma

K Jiang, X Yin, Q Zhang, J Yin, Q Tang, M Xu, L Wu… - Redox biology, 2023 - Elsevier
Radioresistance is the major reason for the failure of radiotherapy in esophageal squamous
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …

The significance of Stanniocalcin 2 in malignancies and mechanisms

S Li, Q Huang, D Li, L Lv, Y Li, Z Wu - Bioengineered, 2021 - Taylor & Francis
ABSTRACT Human stanniocalcin 2 (STC2) is an ortholog of fish stanniocalcins (STCs) and
is widely expressed in various organs and tissues. The gene is localized on chromosome …

Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer

YN Liu, MF Tsai, SG Wu, TH Chang… - … Journal of Cancer, 2019 - Wiley Online Library
Constitutive activation of the epidermal growth factor receptor (EGFR) signaling pathway is
implicated in the initiation and progression of lung cancer. EGFR tyrosine kinase inhibitor …

[HTML][HTML] Deregulated expression of HDAC3 in colorectal cancer and its clinical significance

M Nemati, N Ajami, MA Estiar… - … in Clinical and …, 2018 - advances.umw.edu.pl
Background. To date, 4 classes of histone deacetylases (HDACs) have been identified in
humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include …

Effect of STC2 gene silencing on colorectal cancer cells

Q Li, X Zhou, Z Fang, Z Pan - Molecular medicine …, 2019 - spandidos-publications.com
Abstract Stanniocalcin 2 (STC2), a secretory glycoprotein hormone, regulates many
biological processes including cell proliferation, apoptosis, tumorigenesis and …

Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer

K Yokoi, K Yamashita, S Ishii, T Tanaka… - British journal of …, 2017 - nature.com
Background: Neoadjuvant chemoradiotherapy (NCRT) for advanced rectal cancer (RC) is a
well-evidenced therapy; however, some RC patients have no therapeutic response. Patient …

Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans

M Maciukiewicz, AK Tiwari, CC Zai, I Gorbovskaya… - Schizophrenia …, 2019 - Elsevier
Background Antipsychotic (AP) medications are the first line of treatment for schizophrenia.
However, most conferr a risk of antipsychotic-induced weight gain (AIWG). The objective of …

Stanniocalcin 2 induces oxaliplatin resistance in colorectal cancer cells by upregulating P-glycoprotein

Q Yuan, L Zhan, LL Zhang, Q Wang… - Canadian journal of …, 2016 - cdnsciencepub.com
Multidrug resistance (MDR) limits the anticancer effects of chemotherapy in patients with
metastatic colorectal cancer (CRC). Oxaliplatin is a common component of combinational …

Identifying a Risk Signature of Methylation-Driven Genes as a Predictor of Survival Outcome for Colon Cancer Patients

B Zhao, J Wang, G Sheng, Y Wang, T Yang… - Applied Biochemistry and …, 2024 - Springer
Aberrant expression of gene is driven by its promoter methylation and is the key molecular
basis of carcinogenic processes. This study aimed at identifying a risk signature of …