DNA double-strand breaks (DSBs) affect chromatin integrity and impact DNA-dependent
processes such as transcription. Several studies revealed that the transcription of genes …

The trimeric RNA polymerase complex (3P, for PA-PB1-PB2) of influenza A virus (IAV) is an
important viral determinant of pathogenicity and host range restriction. Specific interactions …

The DNA‐dependent protein kinase (DNA‐PK) is a trimeric factor originally identified as an
enzyme that becomes activated upon incubation with DNA. Genetic defects in either the …

Previous reports have suggested a connection between reduced levels of the catalytic
subunit of DNA-dependent protein kinases (DNA-PKcs), a component of the …

The androgen receptor (AR) dynamically assembles and disassembles multicomponent
receptor complexes in order to respond rapidly and reversibly to fluctuations in androgen …

While diverse enzymatic activities are required for transcriptional initiation, a central
question remains whether additional enzymatic activities involved in other cellular …

Aims: To investigate whether aberrant methylation of the ATM promoter or loss of the
catalytic subunit of DNA‐dependent protein kinase (DNA‐PKcs) may be the underlying …

Nuclear receptors mediate gene activation through ligand-dependent interaction with
coactivators. We previously cloned and characterized thyroid hormone receptor-binding …

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8B8?*+)(! 3 (=: DCA8B:(: E> 5: B3) C:-> &4> 3B;:>? 8B*+)(! 8@: B: DCB:'':= FB: 3'> 43 (4 …

Recombinant adeno-associated viruses (rAAVs) have attracted considerable interest as
gene delivery systems because they show long-term expression in vivo and transduce …