Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and
generating in-demand neutrophils through a process called emergency granulopoiesis …

Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune
responses and inflammation. In the context of colitogenic T cells and IBD, there has been …

Mitochondrial activation and the production of mitochondrial reactive oxygen species
(mROS) are crucial for CD4+ T cell responses and have a role in naïve cell signaling after …

Mitochondria are principal metabolic organelles that are increasingly unveiled as immune
regulators. However, it is currently not known whether mitochondrial-encoded peptides …

Treg cells are the immune system's in-house combatants against pathological immune
activation. Because they are vital to maintenance of peripheral tolerance, it is important to …

Aging promotes numerous intracellular changes in T cells that impact their effector function.
Our data show that aging promotes an increase in the localization of STAT3 to the …

Despite virologic suppression, people living with HIV (PLWH) remain at risk for developing
cognitive impairment, with aberrations in motor control being a predominant symptom …