The rapid growth of biotherapeutic industry, with more and more complex molecules
entering the market, forces the need for advanced analytical platforms that can quickly and …

The multi-attribute method (MAM), a liquid chromatography-mass spectrometry (LC-MS)-
based peptide mapping method, has gained increased interest and applications in the …

Biopharmaceutical products have seen rapid growth over the past few decades and
continue to dominate the global pharmaceutical market. Aligning with the quality by design …

Multi-attribute methods employing mass spectrometry are applied throughout the
biopharmaceutical industry for product and process characterization purposes but are not …

The multi‐attribute method (MAM) has emerged significantly in recent years to support
biotherapeutic protein characterization from process development to the QC environment …

Peptide mapping with mass spectrometry (MS) is an important tool for protein
characterization in the biopharmaceutical industry. Historically, peptide mapping monitors …

The oxidation of the complementarity-determining region (CDR) in monoclonal antibodies
(mAbs) is a critical quality attribute that can affect the clinical efficacy and safety of …

The development of liquid chromatography UV and mass spectrometry (LC-UV–MS) assays
in pharmaceutical analysis is pivotal to improve quality control by providing critical …

Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) can
impact the efficacy of a drug. Methionine oxidation can alter the overall hydrophobicity of an …