Tubulin, an important target in tumor therapy, is one of the hotspots in the field of
antineoplastic drugs in recent years, and it is of great significance to design and screen new …

The unique characteristics of the tumor vasculature offer the possibility to selectively target
tumor growth and vascularization using tubulin-destabilizing agents. Evidence accumulated …

In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among
these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity …

Preclinical and clinical studies have demonstrated the synergistic effect of microtubule-
targeting agents in combination with Janus kinase 2 (JAK2) inhibitors, prompting the …

Abstract A series of 1, 2, 4-triazolo [1, 5-a] pyrimidine derivatives have been designed and
synthesized as combretastatin CA-4 analogs. They were screened for anticancer and tubulin …

Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine
binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the …

Abstract Imidazo [4, 5-b] pyridine derived acrylonitriles were synthesized and explored for
their in vitro antiproliferative effect on a diverse human cancer cell line panel. Three …

KXO1 (tirbanibulin or KX2–391) is as a non-ATP-competitive inhibitor of SRC proto-
oncogene nonreceptor tyrosine kinase (SRC) and is being clinically investigated for the …

We present the design, synthesis and biological activity of novel N-substituted
benzimidazole based acrylonitriles as potential tubulin polymerization inhibitors. Their …

A series of indole-based [1, 2, 4] triazolo [4, 3-a] pyridine derivatives was designed and
synthesized as novel microtubulin polymerization inhibitors by using a conformational …