Sustainability assessment of mechanochemistry by using the twelve principles of green chemistry

KJ Ardila‐Fierro, JG Hernández - ChemSusChem, 2021 - Wiley Online Library
In recent years, mechanochemistry has been growing into a widely accepted alternative for
chemical synthesis. In addition to their efficiency and practicality, mechanochemical …

Advancing mechanochemical synthesis by combining milling with different energy sources

V Martinez, T Stolar, B Karadeniz, I Brekalo… - Nature Reviews …, 2023 - nature.com
Owing to its efficiency and unique reactivity, mechanochemical processing of bulk solids has
developed into a powerful tool for the synthesis and transformation of various classes of …

Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Tribochemistry, mechanical alloying, mechanochemistry: what is in a name?

AAL Michalchuk, EV Boldyreva, AM Belenguer… - Frontiers in …, 2021 - frontiersin.org
Over the decades, the application of mechanical force to influence chemical reactions has
been called by various names: mechanochemistry, tribochemistry, mechanical alloying, to …

Mechanochemical and mechanoenzymatic synthesis of pharmacologically active compounds: A green perspective

M Pérez-Venegas, E Juaristi - ACS Sustainable Chemistry & …, 2020 - ACS Publications
Recently, the application of mechanochemical strategies in organic synthesis has attracted
the attention of both the academic and industrial chemical communities. The high efficiency …

Methods for monitoring milling reactions and mechanistic studies of mechanochemistry: a primer

PA Julien, T Friščić - Crystal Growth & Design, 2022 - ACS Publications
Mechanochemistry by ball milling is garnering significant attention as an efficient and
versatile means of chemical synthesis which minimizes the need for solvents and reduces …

Role of mixing and milling in mechanochemical synthesis

OV Lapshin, EV Boldyreva, VV Boldyrev - Russian Journal of Inorganic …, 2021 - Springer
Selected topics of inorganic mechanochemical synthesis are discussed. Variant
mechanochemical syntheses are considered. The ex situ and in situ/operando methods to …

Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions

S Lukin, K Užarević, I Halasz - Nature Protocols, 2021 - nature.com
Solid-state milling has emerged as an alternative, sustainable approach for preparing
virtually all classes of compounds and materials. In situ reaction monitoring is essential to …

Tinkering with mechanochemical tools for scale up

JF Reynes, V Isoni, F García - … Chemie International Edition, 2023 - Wiley Online Library
Mechanochemistry provides an environmentally benign platform to develop more
sustainable chemical processes by limiting raw materials, energy use, and waste generation …

Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs

LM Martínez, J Cruz-Angeles, M Vázquez-Dávila… - Pharmaceutics, 2022 - mdpi.com
Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …