Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness

A Cruz-Hernandez, A Roney, DG Goswami… - Inhalation …, 2022 - Taylor & Francis
Over 40% of veterans from the Persian Gulf War (GW)(1990–1991) suffer from Gulf War
Illness (GWI). Thirty years since the GW, the exposure and mechanism contributing to GWI …

Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model

E Wigenstam, E Artursson, A Bucht… - Toxicology Mechanisms …, 2023 - Taylor & Francis
The carbamate pyridostigmine bromide (PB) is the only fielded pharmacological prophylaxis
for military use against nerve agents. Previous studies have shown differences in the PB …

Characterization of cholinesterases from multiple large animal species for medical countermeasure development against chemical warfare nerve agents

KG McGarry, KE Schill, TP Winters… - Toxicological …, 2020 - academic.oup.com
Organophosphorus (OP) compounds, which include insecticides and chemical warfare
nerve agents (CWNAs) such as sarin (GB) and VX, continue to be a global threat to both …

Organophosphate detoxification by membrane-engineered red blood cells

PN Smith, L Mao, K Sinha, AJ Russell - Acta Biomaterialia, 2021 - Elsevier
Biotherapeutics have achieved global economic success due to their high specificity
towards their drug targets, providing exceptional safety and efficiency. The ongoing shift …

Current progress for retrospective identification of nerve agent biomarkers in biological samples after exposure

J Wang, X Lu, R Gao, C Pei, H Wang - Toxics, 2022 - mdpi.com
Organophosphorus neurotoxic agents (OPNAs) seriously damage the nervous system,
inhibiting AChE activity and threatening human health and life. Timely and accurate …

[PDF][PDF] Red Blood Cells: Leveraging the Body for the Enhanced Delivery of Biotherapeutics

P Smith - 2022 - kilthub.cmu.edu
Red blood cells (RBCs) have been extensively studied as a potential biotherapeutic delivery
system for several decades. This research has been prompted by these cells' remarkable …

Sintesi di nuove N-(acil)-2-metossifenotiazine quali potenziali inibitori della Butirrilcolinesterasi

P Schenone - 2021 - unire.unige.it
Negli ultimi anni la butirrilcolinesterasi (BChE) ha assunto importanza in campo
farmaceutico. Nell'introduzione sono trattate le informazioni strutturali della BChE e delle …

Recent Trend in Bioscavengers for Inactivation of Toxic Organophosphorus Compounds

H Kim, K Jeong, YS Kye - Applied Chemistry for Engineering, 2020 - koreascience.kr
In recent years, toxic organophosphorus compounds (OPs) have been used for civilians,
becoming a great threat to the world. Alternative to the current treatment policy unpredictable …

유기인계열독성물질분해를위한바이오스캐빈저최신연구동향

김희정, 정근홍, 계영식 - Applied Chemistry for Engineering, 2020 - papersearch.net
초 록최근 몇 년간 유기인 계열 독성물질이 민간인을 대상으로 사용되어 전 세계적으로 큰
위협이 되고 있다. 독성물질에대한 예방이 불가능한 현 치료대책 대신, 보다 개선된 치료 …