Thrombolytic therapies for acute ischemic stroke are widely available but only result in
recanalization early enough, to be therapeutically useful, in 10% to 30% of cases. This large …

The blood–brain barrier constitutes a dynamic and interactive boundary separating the
central nervous system and the peripheral circulation. It tightly modulates the ion transport …

Cerebral ischemia impairs blood circulation, leading to elevated reactive oxygen species
(ROS) production. A ROS-responsive delivery of drugs can enhance the therapeutic efficacy …

In recent years, significant advancements have been made in utilizing nanoparticles (NPs)
to modulate immune responses within the central nervous system (CNS), offering new …

A stroke, also known as a cerebrovascular accident (CVA), is a medical emergency that
occurs when the brain's blood supply is interrupted. This disruption can happen in two main …

Stroke is one of the most common causes of death and disability. In addition, most
neuroprotective agents fail to rescue neurons from cerebral ischemic insults due to their …

Nanomedicine, leveraging the unique properties of nanoparticles, has revolutionized the
diagnosis and treatment of neurological diseases. Among various nanotechnological …

This review offers a comprehensive exploration of optimized drug delivery systems tailored
for controlled release and their crucial role in addressing cerebrovascular diseases …

Cardiovascular Diseases (CVDs) are responsible for the highest number of deaths and
disabilities globally. Although numerous therapeutic options exist for treating CVDs, most …

Acute ischemic stroke is one of the leading causes of morbidity and mortality worldwide.
Restoration of cerebral blood flow to affected ischemic areas has been the cornerstone of …