The dimorphic fungus Candida albicans is both a harmless commensal organism on
mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the …

Highlights•Tissue-resident macrophages are central to counteract systemic candidiasis.•
Macrophages engulf yeast but struggle with hypha, forming frustrated phagosomes.•C …

Phagolysosomes are crucial organelles during the elimination of pathogens by host cells.
The maintenance of their membrane integrity is vital during stressful conditions, such as …

营养元素是白念珠菌定植和致病的关键因素之一, 作为人体真菌微生物组的一部分,
白念珠菌能够特异性感应宿主微环境中营养物质的变化, 及时做出适应性反应, 为其生长 …

Survival of the pathogenic yeast Candida albicans depends upon assimilation of
fermentable and non-fermentable carbon sources detected in host microenvironments …

Macrophages provide the first-line defense against invasive fungal infections and, therefore,
escape from macrophage becomes the basis for the establishment of Candida albicans …