BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

As adults, our health can be influenced by a range of lifestyle and environmental factors,
increasing the risk for developing a series of non-communicable diseases such as type 2 …

Normal spermatogenesis and sperm function are crucial for male fertility. The effects of
healthy testicular aging and testicular premature aging on spermatogenesis, sperm function …

Maternal recognition of pregnancy (MRP) is a process by which an early conceptus signals
its presence to the maternal system and prevents the lysis of the corpus luteum, thus …

Paternal aging has consistently been linked to an increased risk of neurodevelopmental
disorders, including autism spectrum disorder (ASD), in offspring. Recent evidence has …

Cellular fate and gene expression patterns are modulated by different epigenetic factors
including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic …

The genetic and phenotypic heterogeneity of autism spectrum disorder (ASD) impedes the
unification of multiple biological hypotheses in an attempt to explain the complex features of …

Background The number of women delivering at advanced maternal age (AMA;>= 35)
continuously increases in developed and high‐income countries. Large cohort studies have …

There is strong evidence that obesity is a risk factor for poor semen quality. However, the
effects of multigenerational paternal obesity on the susceptibility to cadmium (a reproductive …