Direct and indirect pathways of basal ganglia: a critical reappraisal
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …
[HTML][HTML] Dystonia and dopamine: from phenomenology to pathophysiology
A line of evidence suggests that the pathophysiology of dystonia involves the striatum,
whose activity is modulated among other neurotransmitters, by the dopaminergic system …
whose activity is modulated among other neurotransmitters, by the dopaminergic system …
Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors
PE Rothwell, MV Fuccillo, S Maxeiner, SJ Hayton… - Cell, 2014 - cell.com
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …
corresponding mutations produce robust synaptic and behavioral changes. However …
ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli
MK Lobo, S Zaman, DM Damez-Werno… - Journal of …, 2013 - Soc Neuroscience
The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several
chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress …
chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress …
Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice
JS Schor, IG Montalvo, PWE Spratt, RJ Brakaj… - Elife, 2022 - elifesciences.org
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …
WA Toy, GM Petzinger, BJ Leyshon, GK Akopian… - Neurobiology of …, 2014 - Elsevier
Exercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in
our lab has been to investigate how exercise modulates basal ganglia function and modifies …
our lab has been to investigate how exercise modulates basal ganglia function and modifies …
Dopamine D 1 or D 2 receptor‐expressing neurons in the central nervous system
Dopamine signals mainly through D1 receptors (D1Rs) and D2 receptors (D2Rs); D1R‐
expressing or D2R‐expressing neurons contribute to distinct reward and addictive …
expressing or D2R‐expressing neurons contribute to distinct reward and addictive …
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
BD Heifets, JS Salgado, MD Taylor… - Science translational …, 2019 - science.org
The extensively abused recreational drug (±) 3, 4-methylenedioxymethamphetamine
(MDMA) has shown promise as an adjunct to psychotherapy for treatment-resistant …
(MDMA) has shown promise as an adjunct to psychotherapy for treatment-resistant …
Cell-type specific insertion of GluA2-lacking AMPARs with cocaine exposure leading to sensitization, cue-induced seeking, and incubation of craving
Addiction is a behavioral disease, of which core components can be modeled in rodents.
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …
Much evidence implicates drug-evoked synaptic plasticity in cocaine-evoked locomotor …
An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye
During mouse postnatal eye development, the embryonic hyaloid vascular network
regresses from the vitreous as an adaption for high-acuity vision. This process occurs with …
regresses from the vitreous as an adaption for high-acuity vision. This process occurs with …