A number of mutations to members of several CNS potassium (K) channel families have
been identified which result in rare forms of neonatal onset epilepsy, or syndromes of which …

A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …

The spatial and temporal balance of spinal α‐motoneuron (αMN) intrinsic membrane
conductances underlies the neural output of the final common pathway for motor commands …

Among the five KCNQ channels, also known as the K v 7 voltage-gated potassium (K v)
channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2–KCNQ5 …

Dopaminergic signaling in the nucleus accumbens shell (NAc) regulates neuronal activity
relevant to reward-related learning, including cocaine-associated behaviors. Although …

The central pattern generator (CPG) for locomotion is a set of pacemaker neurons endowed
with inherent bursting driven by the persistent sodium current (I NaP). How they proceed to …

The antidiabetic drug empagliflozin is reported to produce a range of cardiovascular effects,
including a reduction in systemic blood pressure. However, whether empagliflozin directly …

Epilepsy is a chronic brain disease that makes serious cognitive and motor retardation. Ion
channels affect the occurrence of epilepsy in various ways, but the mechanisms have not yet …

Background Microglia are essential to maintain cell homeostasis in the healthy brain and
are activated after brain injury. Upon activation, microglia polarize towards different …

Opening of large conductance calcium-activated and voltage-dependent potassium (BKCa)
channels hyperpolarizes plasma membranes of smooth muscle (SM) to cause vasodilation …