Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility

G Fiorentino, D Cimadomo, F Innocenti… - Human …, 2023 - academic.oup.com
BACKGROUND Folliculogenesis occurs in the highly dynamic environment of the ovary.
Follicle cyclic recruitment, neo-angiogenesis, spatial displacement, follicle atresia and …

Therapeutic options for premature ovarian insufficiency: an updated review

Q Huang, S Chen, J Chen, Q Shi, S Lin - Reproductive Biology and …, 2022 - Springer
Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

Amniotic fluid-derived exosomes attenuated fibrotic changes in POI rats through modulation of the TGF-β/Smads signaling pathway

N Nazdikbin Yamchi, S Ahmadian, H Mobarak… - Journal of Ovarian …, 2023 - Springer
In the current study, we investigated the regenerative effects of amniotic fluid exosomes (AF-
Exos) in a rat model for premature ovarian insufficiency (POI). POI is a condition …

Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action

S Seckin, H Ramadan, M Mouanness… - Journal of assisted …, 2022 - Springer
Purpose Platelet-rich plasma (PRP) therapy has been used as an adjunct to fertility
treatments in women with very low ovarian reserve and premature ovarian insufficiency …

Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?

L Atkinson, F Martin, RG Sturmey - Human Reproduction, 2021 - academic.oup.com
The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related
declines in fertility or in pathological conditions such as premature ovarian failure. The …

Effects of single and multiple transplantations of human umbilical cord mesenchymal stem cells on the recovery of ovarian function in the treatment of premature …

X Lv, C Guan, Y Li, X Su, L Zhang, X Wang… - Journal of Ovarian …, 2021 - Springer
Background Currently, there is no effective treatment for premature ovarian failure (POF),
and stem cell therapy is considered the most promising treatment. Human umbilical cord …

Melatonin and endothelial cell-loaded alginate-fibrin hydrogel promoted angiogenesis in rat cryopreserved/thawed ovaries transplanted to the heterotopic sites

M Izadpanah, AR Del Bakhshayesh, Z Bahroudi… - Journal of Biological …, 2023 - Springer
Background Ischemic niche can promote follicular atresia following the transplantation of
cryopreserved/thawed ovaries to the heterotopic sites. Thus, the promotion of blood supply …

Menstrual blood CD146+ mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure

NN Yamchi, R Rahbarghazi, AM Bedate… - Cell Biochemistry …, 2021 - Wiley Online Library
Here, the regenerative potential of menstrual blood–derived mesenchymal stem cells
(MenSCs) was examined on restoration of premature ovarian failure (POF) ovaries in rats' …

The Clinical Application of Platelet-Rich Plasma in the Female Reproductive System: A Narrative Review

S Vali, S Saso, T Bracewell Milnes, J Nicopoullos… - Life, 2023 - mdpi.com
Platelet-rich plasma is an autologous plasma containing platelets prepared from fresh whole
blood drawn from a peripheral vein. Through processing, it can be prepared to contain …

Revitalising female fertility: platelet-rich plasma (PRP)-hype or hope?

M Serdarogullari, G Raad, S Makieva, G Liperis… - Reproductive …, 2024 - Elsevier
Platelet-rich plasma (PRP) has gained popularity as an experimental tool in regenerative
medicine, with potential applications in reproductive medicine. This review assesses the …