Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Controlling vector-borne diseases by releasing modified mosquitoes

HA Flores, SL O'Neill - Nature Reviews Microbiology, 2018 - nature.com
Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are
becoming major global health emergencies while old threats, such as yellow fever, are re …

Development of a confinable gene drive system in the human disease vector Aedes aegypti

M Li, T Yang, NP Kandul, M Bui, S Gamez, R Raban… - Elife, 2020 - elifesciences.org
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

Apparent competition

RD Holt, MB Bonsall - Annual Review of Ecology, Evolution, and …, 2017 - annualreviews.org
Most species have one or more natural enemies, eg, predators, parasites, pathogens, and
herbivores, among others. These species in turn typically attack multiple victim species. This …

Genetic control of mosquitoes

L Alphey - Annual review of entomology, 2014 - annualreviews.org
Genetics can potentially provide new, species-specific, environmentally friendly methods for
mosquito control. Genetic control strategies aim either to suppress target populations or to …

Bad guys turned nice? A critical assessment of Wolbachia mutualisms in arthropod hosts

R Zug, P Hammerstein - Biological Reviews, 2015 - Wiley Online Library
Wolbachia are the most abundant bacterial endosymbionts among arthropods. Although
maternally inherited, they do not conform to the widespread view that vertical transmission …

Beyond insecticides: new thinking on an ancient problem

EA McGraw, SL O'neill - Nature Reviews Microbiology, 2013 - nature.com
Vector-borne disease is one of the greatest contributors to human mortality and morbidity
throughout the tropics. Mosquito-transmitted diseases such as malaria, dengue, yellow fever …

Harnessing mosquito–Wolbachia symbiosis for vector and disease control

K Bourtzis, SL Dobson, Z Xi, JL Rasgon, M Calvitti… - Acta tropica, 2014 - Elsevier
Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major
vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of …

The intestinal immune defense system in insects

T Zeng, S Jaffar, Y Xu, Y Qi - International Journal of Molecular Sciences, 2022 - mdpi.com
Over a long period of evolution, insects have developed unique intestinal defenses against
invasion by foreign microorganisms, including physical defenses and immune responses …

Mosquito microbiota and implications for disease control

H Gao, C Cui, L Wang, M Jacobs-Lorena, S Wang - Trends in parasitology, 2020 - cell.com
Mosquito-transmitted diseases account for about 500 000 deaths every year. Blocking these
pathogens in the mosquito vector before they are transmitted to humans is an effective …