Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future …
PY Wen, M Weller, EQ Lee, BM Alexander… - Neuro …, 2020 - academic.oup.com
Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …
cause of morbidity and mortality. In recent years there have been important advances in …
[HTML][HTML] Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance
J Cooper, FG Giancotti - Cancer cell, 2019 - cell.com
Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma
A Mackay, A Burford, D Carvalho, E Izquierdo… - Cancer cell, 2017 - cell.com
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse
intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of> …
intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of> …
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily
in the midline of the central nervous system of young children, suggesting a cooperation …
in the midline of the central nervous system of young children, suggesting a cooperation …
Epidemiology and outcome of glioblastoma
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. With an
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
Spatially controlled construction of assembloids using bioprinting
The biofabrication of three-dimensional (3D) tissues that recapitulate organ-specific
architecture and function would benefit from temporal and spatial control of cell-cell …
architecture and function would benefit from temporal and spatial control of cell-cell …
Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of
somatic glioma driving alterations and suboptimal disease classification. We defined the …
somatic glioma driving alterations and suboptimal disease classification. We defined the …
Insulator dysfunction and oncogene activation in IDH mutant gliomas
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic
classes of gliomas,. Mutant IDH protein produces a new onco-metabolite, 2 …
classes of gliomas,. Mutant IDH protein produces a new onco-metabolite, 2 …