Structural dynamics in chromatin unraveling by pioneer transcription factors
A Orsetti, D van Oosten, RG Vasarhelyi… - Biophysical …, 2024 - Springer
Pioneer transcription factors are proteins with a dual function. First, they regulate
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …
[HTML][HTML] Unveiling structural and dynamical features of chromatin using NMR spectroscopy
X Shi - Magnetic Resonance Letters, 2024 - Elsevier
Eukaryotic deoxyribonucleic acid (DNA) is wrapped around histone octamers (HOs) to form
nucleosome core particles (NCPs), which in turn interact with linker DNA and linker histones …
nucleosome core particles (NCPs), which in turn interact with linker DNA and linker histones …
[HTML][HTML] PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
CC Sang, G Moore, M Tereshchenko, H Zhang… - EMBO …, 2024 - pmc.ncbi.nlm.nih.gov
Poly (ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and
plays crucial roles in recruiting DNA repair proteins through its activity–poly (ADP-ribosyl) …
plays crucial roles in recruiting DNA repair proteins through its activity–poly (ADP-ribosyl) …
Angiopoietin-like protein 8 directs DNA damage responses towards apoptosis by stabilizing PARP1-DNA condensates
J Yang, S Wan, Q Song, Y Xie, J Wan, Y Zhou… - Cell Death & …, 2024 - nature.com
Upon genotoxic stresses, cells employ various DNA damage responses (DDRs), including
DNA damage repair or apoptosis, to safeguard genome integrity. However, the determinants …
DNA damage repair or apoptosis, to safeguard genome integrity. However, the determinants …
[HTML][HTML] Molecular and toxicological mechanisms behind the effects of chromium (VI) on the male reproductive system of Mytilus galloprovincialis: First evidence for …
C Marinaro, A Marino, AR Bianchi, B Berman… - Chemico-Biological …, 2024 - Elsevier
Studies on the molecular mechanisms of heavy metal toxicity in invertebrate reproduction
are limited. Given that PARP-catalysed ADP-ribosylation is also involved in counteracting …
are limited. Given that PARP-catalysed ADP-ribosylation is also involved in counteracting …
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
C Chin Sang, G Moore, M Tereshchenko, H Zhang… - EMBO …, 2024 - embopress.org
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA
damage and plays crucial roles in recruiting DNA repair proteins through its activity–poly …
damage and plays crucial roles in recruiting DNA repair proteins through its activity–poly …
PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis
Y Qin, X Dong, M Lu, L Jing, Q Chen, F Guan, Z Xiang… - Cancer Letters, 2024 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear protein that attaches
negatively charged poly (ADP-ribose)(PAR) to itself and other target proteins. While its …
negatively charged poly (ADP-ribose)(PAR) to itself and other target proteins. While its …
PARticular MARks: Histone ADP-ribosylation and the DNA Damage Response
Cellular and molecular responses to DNA damage are highly orchestrated and dynamic,
acting to preserve the maintenance and integrity of the genome. Histone proteins bind DNA …
acting to preserve the maintenance and integrity of the genome. Histone proteins bind DNA …
[HTML][HTML] New facets in the chromatin-based regulation of genome maintenance
J Dabin, G Giacomini, E Petit, SE Polo - DNA repair, 2024 - Elsevier
The maintenance of genome integrity by DNA damage response machineries is key to
protect cells against pathological development. In cell nuclei, these genome maintenance …
protect cells against pathological development. In cell nuclei, these genome maintenance …
Exploring factors influencing choice of DNA double-strand break repair pathways
D Otarbayev, K Myung - DNA repair, 2024 - Elsevier
DNA double-strand breaks (DSBs) represent one of the most severe threats to genomic
integrity, demanding intricate repair mechanisms within eukaryotic cells. A diverse array of …
integrity, demanding intricate repair mechanisms within eukaryotic cells. A diverse array of …