Adult mesenchymal stem cells are a resource for autologous and allogeneic cell therapies
for immune-modulation and regenerative medicine. However, patients most in need of such …

Human aging is associated with bone loss leading to bone fragility and increased risk of
fractures. The cellular and molecular causes of age‐related bone loss are current intensive …

Microvesicle-and exosome-mediated transport of microRNAs (miRNAs) represents a novel
cellular and molecular pathway for cell–cell communication. In this study, we tested the …

Extracellular vesicles (EVs) are known to play important roles in cell-cell communication.
Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of …

Aging has less effect on adipose‐derived mesenchymal stem cells (ADSCs) than on bone
marrow‐derived mesenchymal stem cells (BMSCs), but whether the fact holds true in stem …

Elucidation of the periosteum and its regenerative potential has become a hot topic in
orthopedics. Yet few review articles address the unique features of periosteum-derived cells …

Musculoskeletal aging encompasses the decline in bone and muscle function, leading to
conditions such as frailty, osteoporosis, and sarcopenia. Unraveling the underlying …

Disuse osteoporosis (DOP) is a common complication resulting from the lack of or disuse of
mechanical loading and has been unsatisfactorily treated. We hypothesized that exosomes …

With advancing age bone marrow is progressively replaced with adipose tissue,
accompanied by a concomitant decline in bone mass and strength. The mechanism …

Age‐dependent bone loss occurs in humans and in several animal species, including
rodents. The underlying causal mechanisms are probably multifactorial, although an age …