Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the
mitochondrial matrix. The carrier cycles by an unresolved mechanism between the …

Functional and structural studies of membrane proteins usually require overexpression of
the proteins in question. Often, however, the 'trial and error'approaches that are mainly used …

Copper is required for the activity of cytochrome c oxidase (COX), the terminal electron-
accepting complex of the mitochondrial respiratory chain. The likely source of copper used …

Ligands selected from phage-displayed random peptide libraries tend to be directed to
biologically relevant sites on the surface of the target protein. Consequently, peptides …

Mitochondrial carriers transport nucleotides, co-factors and metabolic intermediates across
the inner mitochondrial membrane permeability barrier. They belong to a family of …

Roughly one-third of all proteins reside in biological membranes [1, 2]. Integral membrane
proteins (IMPs), which can only be released from the membrane by disruption of the …

Escherichia coli is by far the most widely used bacterial host for the production of membrane
proteins. Usually, different strains, culture conditions and production regimes are screened …

The last four years have brought exciting progress in membrane protein research. Finally
those many efforts that have been put into expression of eukaryotic membrane proteins are …