Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Defects in insulin signalling are among the most common and earliest defects that
predispose an individual to the development of type 2 diabetes,,. MicroRNAs have been …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Adipocytes are embedded in a unique extracellular matrix whose main function is to provide
mechanical support, in addition to participating in a variety of signaling events. During …

Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form
remarkably stable membrane domains at the plasma membrane but can also function as …

Caveolae are small, bulb-shaped plasma membrane invaginations. Mutations that ablate
caveolae lead to diverse phenotypes in mice and humans, making it challenging to uncover …

Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

The endocrine functions of the adipose organ are widely studied at this stage. The adipose
organ, and in particular adipocytes, communicate with almost all other organs. Although …